KANDLELIT

The main inclusion criteria include but are not limited to the following:

1. Has locally advanced unresectable or metastatic solid tumor malignancy other than colorectal cancer and has progressed on, or following, standard of care systemic treatment
2. Has a tumor that demonstrates the presence of Kirsten rat sarcoma (KRAS) G12C mutation

The main exclusion criteria include but are not limited to the following:

1. Has uncontrolled, significant cardiovascular disease or cerebrovascular disease
2. Has known additional malignancy that is progressing or has required active treatment within the past 3 years
3. Has known active central nervous system metastases and/or carcinomatous meningitis and/or primary brain tumors
4. Has active infection, other than those permitted per protocol, requiring systemic therapy
5. Has not adequately recovered from major surgery or has ongoing surgical complications