Clinical trials and Research
At the Jreissati Pancreatic Centre at Epworth, we run clinical trials and research studies covering every phase of cancer diagnosis, treatment and care.
Clinical Trials
ACCENT (AMP945-PC-201)
A Phase 1b/2a, Multicentre, Open Label Study of the Pharmacokinetics, Safety and Efficacy of AMP945 in Combination With Nab-paclitaxel and Gemcitabine in Pancreatic Cancer Patients.
Diagnosis: Metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: Focal adhesion kinase (FAK) inhibitor AMP945 (oral) given prior to dosing with nab-paclitaxel and gemcitabine in first-line setting.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
AMG193 20230223
A Study Evaluating AMG 193 in Combination with Other Therapies in Participants with Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers with Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion
Diagnosis: Locally advanced (Stage III) unresectable or Metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: PRMT5 inhibitor AMG193 (oral) in combination with chemotherapy.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
DINE-PC
Dietetics Intervention and Nutritional Evaluation in Pancreatic Cancer Care (DINE-PC).
Diagnosis: Pancreatic cancer.
Treatment: Dietetics counselling.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill), Epworth Geelong.
DIRECT-InspIRE Australia
Investigation of the safety and efficacy of irreversible electroporation (IRE) using the NanoKnife® System in patients with unresectable stage 3 pancreatic cancer who have received 3 months of chemotherapy.
Diagnosis: Locally advanced (Stage III) unresectable pancreatic ductal adenocarcinoma.
Treatment: Irreversible Electroporation (IRE) with the NanoKnife system (surgical).
Epworth locations: Epworth Freemasons (East Melbourne).
NeoFOL-R
Efficacy of Neoadjuvant FOLFIRINOX in Resectable pancreatic cancer: An international multicentre prospective randomized, controlled trial (NeoFOL-R).
Diagnosis: Resectable pancreatic ductal adenocarcinoma.
Treatment: Surgery with mFOLFIRINOX chemotherapy.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
SPEAR
A Phase 2, Open-Label, Single-Arm Sulfasalazine Monotherapy Trial of Progression-Free Survival In Patients with Pancreatic Adenocarcinoma.
Diagnosis: Locally advanced (Stage III) unresectable or Metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: Sulfasalazine monotherapy (oral).
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne).
SuperQoL
Supplemental Jejunal feeding to Improve Quality of Life (SuperQoL).
Diagnosis: Locally advanced (Stage III) unresectable or metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: Dietetics counselling.
Epworth locations: Epworth Richmond.
TRIPP-FFX
An open-label, multi-centre, randomized study of Targeted Radioactive Intratumoural Placement of Phosphorous-32 (OncoSil™) in addition to FOLFIRINOX chemotherapy versus FOLFIRINOX chemotherapy alone in patients with unresectable locally advanced pancreatic adenocarcinoma.
Diagnosis: Locally advanced (Stage III) unresectable pancreatic ductal adenocarcinoma.
Treatment: P32 Oncosil (brachytherapy device) in combination with mFOLFIRINOX chemotherapy.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
AMG193 20210023
AMG 193, Methylthioadenosine (MTA) Cooperative Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, Alone and in Combination with Docetaxel in Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors (MTAP)
Diagnosis: Locally advanced (Stage III) unresectable or metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: PRMT5 inhibitor AMG193 (oral) monotherapy.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
ASCEND
A Randomised, double-blinded phase II study of gemcitabine and nab-paclitaxel with CEND-1 or placebo in patients with untreated metastatic pancreatic ductal adenocarcinoma.
Diagnosis: Metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: Gemcitabine and nab‐paclitaxel with CEND‐1/LSTA1 or placebo.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
MK9999
A Phase 1/2 Study to Evaluate the Safety and Efficacy of MK-2870 Monotherapy or in Combination With Other Anticancer Agents in Gastrointestinal Cancers.
Diagnosis: Metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: TROP2 inhibitor MK-2870 monotherapy or in combination with chemotherapy.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
YH003004
A phase II, multi-center, open-label study to evaluate the safety and efficacy of YH003 in combination with Toripalimab (anti-PD-1 mAb) in patients with unresectable/ metastatic melanoma and pancreatic ductal adenocarcinoma (PDAC).
Diagnosis: Locally advanced (Stage III) unresectable or Metastatic (Stage IV) pancreatic ductal adenocarcinoma.
Treatment: YH003 (recombinant humanized agonistic CD40 IgG2 mAb) in combination with Toripalimab (anti-PD-1 mAb) with or without nab-paclitaxel + gemcitabine.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
Research Studies
APRISE
The Australian Pancreatic High-RIsk ScrEening (APRISE) Study
Diagnosis or condition: Individuals considered at high-risk of developing pancreatic cancer.
Epworth locations: Epworth Richmond.
MoST
Molecular Screening and Therapeutics Program (MoST)
Diagnosis or condition: Pancreatic cancer.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
OSCILLATE
An Observational Study following Circulating tumour DNA during multi-Agent Therapy in PDAC (OSCILLATE)
Diagnosis or condition: Unresectable pancreatic cancer.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne), Epworth Eastern (Box Hill).
SCANPatient
Synoptic reporting of CT scans assessing cancer of the pancreas
Diagnosis or condition: Suspected diagnosis of pancreatic cancer.
Epworth locations: Epworth Richmond, Epworth Freemasons (East Melbourne).
PaCaSo
The Australian and Aotearoa New Zealand Pancreatic Cancer Surgical Outcomes (PaCaSO) Registry
Diagnosis or condition: Individuals who have experience of pancreatic cancer surgery, as a patient, carer, or loved one.
Epworth locations: Epworth Richmond.
PCB
Pancreaticobiliary Cancer Biobank (PCB)
Diagnosis or condition: Suspected diagnosis of pancreatic cancer or cholangiocarcinoma.
Epworth locations: Epworth Richmond.